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A randomized controlled trial showed that adding infliximab to steroids provided no measurable benefit in the management of newly diagnosed GCAwhen compared to placebo for the treatment of patients with GCA.7
Infliximab as a Palliative Medication
The use of infliximab as a palliative medication can provide patients with a measure of comfort and acceptance, d bal nz. Infliximab has been shown to reduce the incidence and duration of the last period of hospice, enhance hospice care, prevent further end-of-life care, delay the loss of cognitive functions, and improve emotional health, bal d trial free.8 The effects on health care, and on the quality of life, of using this medication as a palliative is of sufficient importance to warrant the development of randomized controlled trials to further validate its use in the treatment of GCA, bal d trial free. Other factors that can impact on the long-term effectiveness of this medication include the need to maintain an infliximab regimen in the long-term (even as a maintenance therapy), the degree of immunological tolerance, and the effect of specific medications.9 The efficacy of adjunctive treatment for GCA remains controversial.10 For example, adjunctive therapy with fluconazole (an antithymocyte antibody) and nivolumab (a cytotoxic chemotherapy) have not demonstrated efficacy for patients with persistent GCA, and nivolumab and fluconazole may have less effect than infliximab on cancer progression.10,11
The recommended dose of infliximab is 0.25 mg once daily or less often with frequent dosing. However, no randomized controlled studies of infliximab for GCA have been published yet, d bal free trial.
The use of topical infliximab is still under investigation. For a review of the efficacy of topical infusions for the treatment of GCA, please see our article on topical infusions.
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